[A] 1.44 Regeneration of epithelial tissue Flashcards
List the locations of epithelial tissue
- Skin
- Mucosa
- Glandular epithelium → Liver, kidney, pancreas, thyroid
- Stratified squamous epithelium → Oesoph., oral cavity
- Columnar epithelium → GI tract, uterus
Regeneration of the skin when: Only the upper layers destroyed
- Abrasion & erosion
- Quick regeneration from the germinative cells
- Stratum germinativum fills the gap
- Irregular epithelial papilla
- Becomes normal later
Regeneration of the skin when: Stratum germinativum is also destroyed
- Ulceration
- Gap is filled with granulation tissue
- Slow proliferation of epithelial cells
- Migrate and cover the granulation tissue
- First in one layer only
- Later becomes stratified
- Frangments of the germinative layer, stemcells of the hair follicles or glands → Better regeneration
Steps of regeneration
- Deep gap (loss of tissue)
- Granulation tissue fills the gap
- Flow proliferation of the epithelial cells
- Epithelial cells migrate and cover
Regeneration of glandular epithelium is dependent on
The degree of tissue damage
- The basement membrane is either intact or destroyed
Regeneration of the glandular epithelium: Intact basement membrane
- Essential for complete regeneration
- The normal arrangement of newly formed cells
- Only epithelial cells were destroyed
- No too excessive injury
- Tubular regeneration
Regeneration of the glandular epithelium: Basement membrane destroyed
No integration into regular structure
- Hypotypia
- Heteromorphosis
Regeneration in the liver: Necrosis alone
Regeneration
Regeneration in the liver: Necrosis + loss of structure
Connective tissue & liver cell proliferation with abnormal structure:
- Hypotypia
- Heteromorphosis
- Cirrhosis
Kidney regeneration: Tubular epithelial cell degeneration
Regeneration
Kidney regeneration: Loss of basement membrane and connective tissue structure
Scar tissue formation
