[A] 1.41 About the regeneration in general, removal of the necrotic tissues

Question 1

Healing of tissue lesions

Answer 1

• Resuscitation (recreatio)
• Replacement
• Regeneration
• Following necrosis
  
  • Preparation, resorption, removal (resorptio, remotio)

Question 2

Regeneration

Answer 2

Regeneratio

• Perfect regeneration (Restitutio ad integrum)
• Imperfect regeneration (Restitutio cum defectu)
  
  • Direct/indirect forms

Question 3

Removal of cells and tissues

Answer 3

1. Prepare cells & tissues for removal using enzymes from:
   
   • Necrotised cells
   • Neighbouring cells
2. Absorption (resorptio)
3. Removal (remotio)

Question 4

Preparation of cells and tissues for removal differs between…

Answer 4

• Colliquative necrosis
• Coagulation necrosis
• On organ surfaces

Question 5

Colliquative necrosis removed by…

Answer 5

• ​Lytic enzymes
• The pathogen
• Organ feature (Brain etc.)

Question 6

Coagulation necrosis is removed by…

Answer 6

• Neutrophil granulocytes
• Heterophil granulocytes

Question 7

Removal from organ surfaces is completed by…

Answer 7

Skin & mucosa

Question 8

Removal of cells and tissues

Answer 8

1. Preparation
2. IC accumulation
3. Excretion to the EC space
4. Histolysis - circulation - lymph nodes
5. Removal (remotio)
6. Resorbed materials

Question 9

Removal of cells and tissues: Resorbed materials are…

Answer 9

• Digested (digestio) - cytosomes
• Excreted - via blood/lymph
• Phagocytes transported
• Stored (thesaurismosis)
• Excreted without digestion - cytopempsis
  
  • Through endothelium

Question 10

Inflammation regeneration

Answer 10

Necrotic tissue induces acute protective inflammation

• Dilation of capillaries bordering the necrotic tissue

Haemorrhagic border

Question 11

Factors influencing regeneration

Answer 11

• Phylogenetics
• Degree of tissue differentiation
• Age
• Condition
• Metabolic disorders
• Infection
• Innervation
• Therapy (E.g steroids)