[A] 1.71 Tumor-induced angiogenesis (capillary incorporation, budding of endothelial cells) Flashcards
1
Q
Neoangiogenesis: Overview
A
- Without angiogenesis - Tumours can’t grow bigger than 1-2mm
- Used for oxygen, nutrients & metabolite removal
- New vessels can produce growth factors
- Opportunity metastasis
2
Q
Neovascularisation
A
New vessels budding
3
Q
Vasculogenesis
A
Bone marrow-derived endothelial cells form a new vascular network
4
Q
VEGF & FGF: Function
A
Produced by neoplastic cells
- Induces angiogenesis
5
Q
Neoangiogenesis involves a balance of…
A
Angiogenic & antiangiogenic factors
- ↑VEGF
- ↑ Proteases
- ↓Thrombospondin-1
6
Q
Antiangiogenic factors: Examples
A
- Angiostatin
- Endostatin
- Vasculostatin
Produced by the split of plasminogen, collagen & transthyretin
Can be used as therapy
7
Q
Neoangiogenesis: Characters of the vessels
A
- Abnormal
- Permeable
- Dilated
- Distorted
8
Q
Lymphangiogenesis
A
- Already existing lymphatic vessels are proliferating
- Inevitable for solid tumour metastasis to lymph nodes
