[B] 1.62 Actinobacillosis, actinomycosis Flashcards
Bacteriology of Actinomyces bovis
- Gram + Rod - Forming filaments
- Blood agar:
- Slow-growing
- Produces wrinkled “molar tooth” colonies
A. bovis: Location and route of entry to the body
- Oral cavity
- Intestines
- Urogenital system
Enter the body through injuries:
- Changing of teeth
- Sharp parts of plants
A. bovis: From the point of infection
- Invasion of deeper tissues
- Characteristic alterations - usually in bones (jaw)
A. israeli affects which species?
Human
Formation of lumpy jaw from the point of infection
- Infection
- Bacilli divide → Serous exudate & neutrophil → Lysis
- Incorrect osteoclast & osteoblast activity
- Spongiform bone formation + Purulent softening “Sulphur granules”
“Sulphur granules”
- A. bovis: In the centre network of filamentous branching threads
- Gram +
- Radially arranged clubs
Actinobacillus lignieresi: General bacteriology
- Cattle & other ruminants
- Gram -, rods or filaments
- Facultative pathogen - present on mucousa
Actinobacillus lignieresi: Injuries of the oral cavity/skin
- Injuries of the oral cavity/skin
- Invasion, carried by the lymph
- Characteristic alterations in soft tissues (Udder, tongue, skin etc)
Actiobacillotic/actinomycotic nodule
- Multiple, pea-sized nodules, sharply demarcated
- Yellow/brown granulation tissue (colour by lipoid granule containing histiocytes)
A. lignieresi: Lesions formed
- Actiobacillotic nodule
- Tumour like growth
- Abscess formation
- Sclerotising form
A. lignieresi: Tumour-like growth
Actinobacilloma
- Consequence of extreme granulation
- Egg-sized
- Cut surface:
- Soft
- Grey-yellow
- Bulging out
- Miliary foci of pus
- Firm connective tissue capsule
A. lignieresi: Abscess formation
Histiolysis increases
- Capsule
- Granulation tissue
- Dense & viscous pus containing sulphur granules
A. lignieresi: Scleroitc form
Healing
- Diffuse
- Overgrowth of connective tissue
- Grey-white, Firm
- Scattered foci (Sulphur granules)
Actiobacillotic/actinomycotic nodule: Steps of formation
Site of infection:
- Bacilli divide
- Serous exudate & neutrophil → Lysis
- Granulation tissue → Connective tissue
- Capsule
Actinobacillar nodules: If pathogens afe killed
- Graduation tissue penetrates towards the centre
- Small fibrotic connective tissue or complete healing