[B] 1.28 Disturbances in keratinization Flashcards

1
Q

Cytoplasmic filaments

A

Prekeratin

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2
Q

Keratohyalin granula

A
  • Autophagocytosis
  • Granular formation
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3
Q

Odland’s granules

A

Granula bordered by membranes

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4
Q

In the hornifying epithelium

A
  • In the skin
  • Modified appendix of the epithelium
    • Hoof & horn
  • Forestomachs
  • Oesophagus
  • On pars oesophagica (stomach)
  • Mouth cavity
    • Differs btw. species
    • On the back of the tongue
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5
Q

Give the process of keratinisation

A
  1. Cytoplasmic filaments
  2. Pre-keratin synthesis
  3. Keratohyalin-granula
  4. Amorphic electrondens granula
  5. Odland-granula formation
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6
Q

Disturbances in keratinisation

A
  • Hyperkeratosis
  • Hypokeratosis
    • Rare
    • Wasting diseases
    • Starvation
  • Parakeratosis
  • Dyskeratosis
    • Keratinisation of the str. spinosum
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7
Q

Hyperkeratosis - Local

A
  • Intense epithelial hyperplasia
  • Intense keratinisation in the str. corneum
  • Cornu cutaneum
  • Hard pad disease
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8
Q

Systemic hyperkeratosis causes

A
  • Vitamin A deficiency
  • Toxicoses: Chlorinated naphthalene
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9
Q

Summarise the forms of keratinisation disturbances

A
  • Hyperkeratosis
  • Congenital - Acquired
  • Local - Generalised
  • Hypokeratosis
  • Parakeratosis
  • Dyskeratosis
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10
Q

Characteristics of hyperkeratosis

A
  • No desquamation
  • Thicker superficial layer
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11
Q

Local hyperkeratosis

A
  • Mechanical cause
  • Chronic inflammation/circulatory disturbance
  • Malformation
  • Trophoneuroticus disturbance
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12
Q

Local hyperkeratosis:

  • Mechanical cause
A
  • Callositas
  • Tyloma/ Callus
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13
Q

Local hyperkeratosis:

  • Chronic inflammation/circulatory disturbance
A

Pachydermia

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14
Q

Local hyperkeratosis:

  • Malformation
A

Cornu cutaneum

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15
Q

Local hyperkeratosis:

  • Trophoneuroticus disturbances
A

Hard pad disease

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16
Q

Generalised hyperkeratosis

A
  • A-avitaminosis
  • Chloronaphthalene intoxication
  • Biotin deficiency (turkey)
  • Toxical floor (piglets)
  • Ichthyosis congenita
    • ​Recessive genetical lethal factor
17
Q

Parakeratosis

A
  • Hornifying layer thicker
  • Nuclei still present close to the surface
    • Skin oedema
    • Chronic inflammation (skin & rumen)
    • Zn-deficiency (Pigs skin)
18
Q

Parakeratosis - Cellular level

A
  • Lack of granules
  • Retained nuclei of epithelial cells in the stratum corneum
19
Q

Hyper- and parakeratosis of the rumen leads to…

A

Liver abscessation

20
Q

Steps of hyper- & parakeratosis of the rumen → Liver abscessation

A
  1. Hyper- & parakeratosis - Locus minoris resistenciae
  2. Colonising pathogenic bacteria
  3. Chronic inflammation
  4. Bacteria in the propria → V. portae → liver
  5. Purulent (pussy), ichorous and/or necrotising inflammation
21
Q

Dyskeratosis

A
  • Keratinisation starts in the stratum spinosum
  • Secondary lesion
  • Rare