[A] 1.52 Proliferative processes during inflammation.

Question 1

Fibrosis

Answer 1

Production of excessive fibrous connective tissue in an organ or tissue as a means of repair.

Rather than as a normal constituent of an organ or tissue

Question 2

Angiogenesis: Physiological & pathological occurances

Answer 2

Physiological in adults:

• Ovarian cycle
• Wound healing

Pathological processes:

• Chronic inflammation
• Tumour induced angiogenesis

Question 3

Give the most important factors inducing angiogenesis

Answer 3

• Vascular endothelial growth factor (VEGF)
• Fibroblast growth factor (FGF)

Question 4

Angiogenesis in chronic inflammation: Major sources of pro-angiogenic factors

Answer 4

• Monocytes
• Lymphocytes
• Macrophages
• Mast cells
• Platelets

Question 5

Angiogenesis in cancer: Major sources of pro-angiogenic factors

Answer 5

• Tumour cells
• Infiltrating leukocytes

Question 6

Pathological types of chronic inflammation

Answer 6

1. Chronic inactive
2. Chronic active
3. Granulomas
4. Pyogranulomas

Question 7

Chronic active inflammation

Answer 7

In the granulation tissue with exsudation, _neutrophil granulocyte_s, macrophage activation