[A] 1.51 Infiltrative processes during acute inflammation Flashcards
1
Q
Cellular infiltration
A
Acute inflammation
- Neutrophils predominate in the first 1-2 days
- These are then replaced by macrophages
2
Q
Chemotaxis
A
After extravasation, leukocytes emigrate in tissues toward the site of injury
- Exogenous & endogenous substances can act as chemoattractants
3
Q
Exogenous chemoattractants
A
Bacterial products
4
Q
Endogenous chemoattractants
A
- Components of the complement system
- Cytokines
- Arachidonic acid metabolites - Leukotriene B4
5
Q
Activation of leukocyte phagocytosis: Steps
A
- Recognition & attachment of the particle to be ingested by the leukocyte
- Engulfment → of phagocytic vacuole forms
- Killing or degeneration of the ingested material
6
Q
Intracellular degradation is either…
A
- Oxygen-dependent
- Oxygen-independent
7
Q
Oxygen-dependent degradation
A
Production of ROS
8
Q
Oxygen-independent degradation
A
Dependent on granule release
- Containing proteolytic enzymes such as defensins, lysozyme and cationic proteins
9
Q
After phagocytosis, neutrophils undergo…
A
Apoptosis
- They are then ingested by macrophages
10
Q
Increased erythrocyte diapedesis in dogs
A
Specific pathobiological inflammatory hallmark
- Responsible for the haemorrhagic appearance of the purulent inflammatory fluid (Pus/exsudate)
11
Q
Immunohistochemistry (IHC) refers to…
A
Detecting antigens in the cell of a tissue
- Exploits the principle of antibodies binding to antigens
12
Q
A
Myeloperoxidase (MPO)
13
Q
A
- CD68 (Cluster of differentiation 68)
- IBA-1 (Ionised calcium-binding adaptor molecule 1)
14
Q
A
CD3
15
Q
A
- CD79a
- CD20
16
Q
A
C-Kit (CD117)
