[B] 1.25 Disturbances in fat metabolism Flashcards

1
Q

Fat substances affected by water balance disturbances

A
  • Simple fats, lipids
  • Compound fats, lipoids
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2
Q

Simple fats, lipids: Examples

A
  • Neutral fats (triglycerides)
  • Waxes
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3
Q

Compound fats, lipoids: Examples

A
  • Phospholipids
  • Glycolipids
  • Steroids
  • Carotinoids
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4
Q

Simple fats: Localisation

A
  • Cells
  • Depots
    • Subcutaneous fat
    • Kidney
    • Under serous membranes
    • Bone marrow
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5
Q

Simple fats: Types

A
  • Stable (structure)
  • Unstable (Transport)
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6
Q

Demonstration of fats

A
  • Similar characteristics
  • Before or after fixation
  • Frozen sections or after embedding
    • Fat solvents
  • Physical = colouring
  • Chemical = staining
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7
Q

Physical staining methods: Fat

A
  • Sudan III, scarlet red
  • Sudan black, osmic acid
  • Oil-red-O
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8
Q

Chemical staining methods: Fat

A
  • Nile blue
  • PAS
  • Schultz method (cholesterol)
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9
Q

Physiological deposition of fat

A
  • Liver
  • Kidney
  • Sebaceous gland
  • Mammary gland
  • Adrenal cortex
  • CNS
  • Leydig-cells
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10
Q

Pathological deposition of fat

A
  • Increased amount
  • Abnormal localisation
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11
Q

Fatty degradation of the liver can occur in…

A
  • Anatomical unit
  • Functional unit
  • Whole organ
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12
Q

Physiological fatty degeneration

A

On the periphery

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13
Q

Pathological fatty degeneration

A

Centrilobular - Diffuse

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14
Q

Types of fatty degeneration

A
  • Simple
  • Necrobiotic
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15
Q

Causes of fatty degeneration

A
  • Oxidation of fatty acids
  • Connection of lipids to apoproteins
  • Apoprotein production
  • Release of lipoprotein
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16
Q

Causes of abnormal fat accumulation

A
  • Overfeeding
  • ↑ fat mobilisation from depots
  • Hypoxia
  • Toxic substances
  • Lack of lipotropic factors
  • Disturbance of carbohydrate metabolism
  • Acidosis, ketosis
17
Q

Lipoidosis (Disorder of lipid metabolism)

A
  • Lipoid thesaurismosis (fat accumulation)
  • Deposition of lipoids
18
Q

Local deposition of lipoids

A
  • Cholesteatoma in the choroid plexus
  • On the pleura
  • Atherosclerosis
19
Q

Systemic deposition of lipoids

A
  • Hereditary, congenital
  • Sphingomyelin, ganglioside, kerazine