[A] 1.43 Organisation, demarcation

Question 1

Direct forms of repair

Answer 1

• Organisation
• Demarcation
• Hypotypia
• Heteromorphosis
• Hyperregeneration & Hypermorphosis

Question 2

Hypotypia

Answer 2

Original cells, but not the original structure

Question 3

Heteromorphosis

Answer 3

Instead of original cells, other (not connective tissue) types of cells

Question 4

Hyperregeneration & hypermorphosis

Answer 4

Fill the area but continue proliferation

Question 5

Summarise organisation

Answer 5

• Supplementation with the original tissue
• But with collagenous fibrous connective tissue

Question 6

Organisation occurs when…

Answer 6

Tissue loss is too large

Question 7

Organisation: Steps of the process

Answer 7

1. Histolysis, resorption & removal
2. New blood vessels
3. Fibroblast differentiation (granulation tissue)

Question 8

Granulation tissue formation timeline

Answer 8

1. First fibroblasts (2-3 days)
2. Collagen fibres (5-7 days)
3. Elastic fibres (4 weeks)

Question 9

Angiofibroblast tissue

Answer 9

1. Fibroblast proliferation & collagen fibres
2. Angiogenesis (capillary loops)
3. Maturation & differentiation

Question 10

Maturation of the granulation tissue

Answer 10

1. Rich in cells
2. Poor in cells
3. Fibre production
4. Mature collagen fibrous connective tissue
5. Shrinking of the tissue
6. Scar (cictrix) formation
   
   • Brain = Glial scar
   • Bone = Callus

Question 11

Demarcation

Answer 11

Basically the same as organisation

• Connective tissue encircles the area
• Necrotised tissue dries
• Secondary calcification might occur

Heterolysis

• Surrounding material fluidise
• Sequestration