6/2

Question 1

which anemia is a splenectomy indicated

Answer 1

hereditary spherocytosis

Question 2

drug to treat ulcerative colitis

Answer 2

sulfasalazine

Question 3

does uric acid precipitate at high or low pH?

Answer 3

low pH

Question 4

areas of nephron with lowest pH

Answer 4

collecting duct, distal tubule

Question 5

if someone with leukemia develops multiple uric acid crystals. think…

Answer 5

tumor lysis syndrome- emergency!

Question 6

where is PAH secreted into

Answer 6

proximal tubule

Question 7

pathogenesis of paraneoplastic cerebellar degeneration (from small cell lung carc, breast, ovarian, uterine cancer)

Answer 7

autoimmune- cross react with purkinje neuron antigens

anti yo, p/q, hu

Question 8

order of arteries involved in atherosclerosis

Answer 8

abdominal aorta > coronary > popliteal > interanl carotid > circle of Willis

Question 9

lymph flow in lower extremeties

Answer 9

medial tracts–> inguinal LAD

lateral tracts –> popliteal and inguinal LAD

Question 10

if someone with RA develops sensory loss and weakness, think…

Answer 10

vertebral subluxation –> spinal cord injury

Question 11

neuroblastoma

Answer 11

develops from adrenal medulla

high n-myc

opsoclonus-myoclonus paraneoplastic

Question 12

spinal stenosis

Answer 12

lumbar region

weakness, pain, paresthesia

better with certain postures- leaning over, walking uphill

degernative arthritis –> IV disc herniation, ligamentum flavum hypertrophy, osteophyte

Question 13

tryptase

Answer 13

enzyme specifically related to mast cells

increased in anaphalyxis

Question 14

mechanism to induce insulin resistance

Answer 14

activate serine or threonine kinases to phosphorylate beta subunits on insulin receptor

dont by TNF alpha, catecholamines, glucagon, glucocorticoids

Question 15

where does parvovirus b19 replicate?

Answer 15

erythrocyte precursors in bm

Question 16

which ulcers are not associated with increased risk of cancer?

Answer 16

duodenal

Question 17

what is normal in ARDS

Answer 17

pulmonary capillary wedge pressure

Question 18

leflunomide MOA and RX and TX

Answer 18

MOA: reversibly inhibits dihydroorate dehdrogenase - prevents pyrmidine synthesis and suppress T cell proliferatio

Rx: RA, psoriasis

Tx: diarrhea, hepatox, HTN, teratogen

Question 19

TNF inhibitors

Answer 19

Etanercept- TNF decoy fusion protein

Infliximab, adalimumab- mabs

Question 20

glucagonoma presentaiton

Answer 20

hyperglycemia (newly presented diabetes)

necrolytic migratory erythema (blistering erythematous plaque with central clearing)- groin, face, extremities

Question 21

what kind of cancer can Rb give later in life

Answer 21

osteosarcomas

Question 22

congenital torticollis

Answer 22

2-4 weeks

cause: malposition of head during utero or birth trauma

head tilted to one side, soft tissue mass, SCM fibrosis

Question 23

DOC for delirium

Answer 23

haloperidol

Question 24

musculoskeletal provides sensory innervation to what part

Answer 24

lateral forearm

Question 25

murmur associated with head bobbing

Answer 25

aortic regurgitation