5/3 Flashcards
what can treat RA fast before DMARDs kick in?
NSAIDs and glucocorticoids
suspensory ligament of ovary contains
ovarian artery, vein, lymphatics and nerves
ligate before surgery to prevent bleeding
it’s a fold of the peritoneum
digoxin toxicity
GI (N/V/anorexia),
CNS (fatigue, weakness, confusion, color vision alteration
Cardiac arrhythmia - life threatening
essential fructosuria vs hereditary fructose intolerance
essential fructosuria:
fructokinase def- benign
hereditary:
aldolase B def- severe
vomiting, hypoglycemia, jaundice, hepatomegaly, failure to thrive
Tumor lysis syndrome
oncologic emergency
during chemo of leukemias/lymphomas when large numbler of tumor cells lyse at same time–> leak intracellular ions
hyperphosphatemia, hypocalcemia, hyperkalemia (–>arrythmia), hyperuricemia (–>obstructive uropathy, renal failure)
to treat tumor lysis syndrome
fluid hydration
allopurinol
rasburicase- recombinant urate oxidase- converts uric acid to be more soluble
what should be ordered before starting statins
liver function tests- due to side effect of myopathy and hepatitis
cavernous sinus trombosis
due to infection spread through sinuses, teeth, or medial third of face
fever, HA, diplopia
injury of CN III, IV, VI
CNIII palsy- also ptosis and mydriasis
CNV- lose sensation on face and afferent corneal limb
proptosis- due to impaired venous draining
if someone has hypertension and their kidneys are small, what should you expect?
renal artery stenosis
toxin of Clostridium perfringens
lecithinase- alpha toxin- degrades lecithin, a component of cellular phospholipid membranes- so splits phosholipids
pulmonary artery occlusion pressure
measured by Swan-Ganz to diagnose pulmonary hypertension
reflects LA and LV end-diastolic pressures
complications of severe aortic stenosis
LV hypertrophy for adequate systole, reduced compliance
so rely on atria for adequate LV filling
but then a common complication is getting afib, so cant rely on atria filling anymore–> decrease LV preload–> hypotension
and back up of pressure –> pulm edema
micturition reflex controlled by…
- sacral micturition center-S2-S4- parasympathetic
- pontine micturition center- in pons reticular fibers- controls relaxing of sphincter
-cerebral cortex- inhibits micturition center
(cortical fibers from cortex to sacral micturution center inhibited in normal pressure hydrocephalus so you get incontinence
what makes up propionyl CoA?
pyrimidines, off-chain fatty acids, and amino acids (valine, isoleucine, methionine, threonine)
PCP (Phencylidine) MOA and effects
NMDA antagonist (n methyl d aspartate)
psychosis, violent, ataxia, nystagmus, delirium
