5/3- Immuno heavy Flashcards
Type of immune cells that attack in various transplant reactions, and time, and type of hypersensitivity reaction: hyperacute, acute, chronic, graft-v-host
Hyperacute (minutes): Recipient pre-existing antibodies (type II) against donor
Acute (weeks-mo): Recipient CD8 against donor (type IV)
Chronic (mo-years): Recipient CD4 against donor peptides brought in by APCs (type II and IV)
Graft-vs-Host (varies): Donor T cells against recipient (type IV)
IL-4 function
growth and differentiation of B cells
B cell isotype switching- esp. to IgE after allergen
differentiation to Th2
IL-5 function
growth and differentiation of B cells
IgA production
Eosinophils
Parasitic activity
Poison ivy is what type of hypersensitivity reaction
type IV- CD8
where does isotype switching occur?
germinal center of lymph node
which CD does isotype switching need and which cytokines stimulate it?
CD40
Il-2,4,5,6, IFNgamma
candidal antigen skin test
assesses T cell activity via type IV hypersensitivity test
uses CD4, CD8, and macrophages
Chediak-Higashi syndrome
Aut rec
defect in lysosomal trafficking regulator gene (LYST) and microtubule function in phag-lys fusion–> defective neutrophils
recurrent pyogenic infections (staph, strep), albinism, neuropathy, neurodegeneration)
giant granules, panctyopenia
Wiskott-Aldrich syndrome
WAS mutation- x linked rec- cant reorganize actin skeleton
Thrombocytopenia, Eczema, recurrent infections
high IgE, IgA
Chronic granulomatous disease
defect of NADPH oxidase– no resp burst in PMNs
x linked rec
susceptible to catalase positive organisms
Leukocyte adhesion deficiency
Aut rec- defect in LFA-1-integrin on phagocytes- no CD18
impaired neutrophil migration to inflamm sites
recurrent bacterial skin and mucosal inf, impaired wound healing, delayed separation of umbilical cord
leukocytosis
Hyper IgM syndrome
defective CD 40 L on TH cells– cant class switch
x linked rec
severe pyogenic infections- Pneumocystis, Crypto, CMV
Ataxia- telengtasia
defect in ATm- cant repair DNA ds breaks
ataxia and telengiectasia
IgA deficiency, high AFP
SCID
defective IL-2R gamma chain (x-linked)
or adensoine deaminase deficiency (aut rec)
diarrhea, thrush, recurrent infections, absent thymic shadow
IL-12 function and deficiency
TH1 differentiation
deficiency: mycobacterial infections. treat with IFNgamma
