5/23 Flashcards
cause of transposition of the great vessels
linear rather than spiral development of articulopulmonary septum in utero
–> anterior aorta connected to RV, and posterior pulm artery connected to LV
orotic aciduria enzyme defect
uridine 5-monophosphate (UMP) synthase
orotic aciduria symptoms
megaloblastic anemia
physical and mental retardation
FTT
which supplement can help orotic aciduria
uridine
pringle maneuver
occluding portal triad to distinguish source of RUQ bleeding
if hepatic bleeding persists–> IVC or hepatic veins
Is red neuron irreversible or reversible injury
irreversible- no nissl, pyknosis of nuclei, shrinkage of cell body, eosinophilic cytoplasm
changes in neurons with normal aging
progressive neuronal atrophy- loss of neurons, gliosis
different types and functions of histones
H2A, H2B, H3, H4- DNA wrapped around 8 core histones (2 of each)
H1- on outside- packages nucleosomes into more compact structures
perfusion-limited
normal resting conditions
PE- severe
tracheal O2 and alveolar O2 are the same
low alveolar pCO2
diffusion-limited respiration
emphysema
pulmonary fibrosis
exercise
alveolar CO2 greater than alveolar O2
gallstone ileus
large gallstone erodes into intestinal lumen via fistula –> bowel obstruction
air in the biliary tract
cells that do antibody-dependent cell-mediated cytotoxicity
neutrophils
macrophages
NK cells
eosinophils
how do stritctures and fistulas form in crohn’s?
transmural inflammation
—> edema and fibrosis –> strictures
–> inflamm and necrosis –> ulcers –> fistulas
where do anal fissures mostly occur
posterior midline of anal verge (decreased blood flow)
why is primaquine added
to get p ovale and vivax in liver (hypnozoites)- prevent relapses