5/23 Flashcards

1
Q

cause of transposition of the great vessels

A

linear rather than spiral development of articulopulmonary septum in utero

–> anterior aorta connected to RV, and posterior pulm artery connected to LV

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2
Q

orotic aciduria enzyme defect

A

uridine 5-monophosphate (UMP) synthase

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3
Q

orotic aciduria symptoms

A

megaloblastic anemia
physical and mental retardation
FTT

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4
Q

which supplement can help orotic aciduria

A

uridine

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5
Q

pringle maneuver

A

occluding portal triad to distinguish source of RUQ bleeding

if hepatic bleeding persists–> IVC or hepatic veins

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6
Q

Is red neuron irreversible or reversible injury

A

irreversible- no nissl, pyknosis of nuclei, shrinkage of cell body, eosinophilic cytoplasm

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7
Q

changes in neurons with normal aging

A

progressive neuronal atrophy- loss of neurons, gliosis

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8
Q

different types and functions of histones

A

H2A, H2B, H3, H4- DNA wrapped around 8 core histones (2 of each)

H1- on outside- packages nucleosomes into more compact structures

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9
Q

perfusion-limited

A

normal resting conditions
PE- severe

tracheal O2 and alveolar O2 are the same
low alveolar pCO2

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10
Q

diffusion-limited respiration

A

emphysema
pulmonary fibrosis
exercise

alveolar CO2 greater than alveolar O2

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11
Q

gallstone ileus

A

large gallstone erodes into intestinal lumen via fistula –> bowel obstruction

air in the biliary tract

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12
Q

cells that do antibody-dependent cell-mediated cytotoxicity

A

neutrophils
macrophages
NK cells
eosinophils

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13
Q

how do stritctures and fistulas form in crohn’s?

A

transmural inflammation

—> edema and fibrosis –> strictures

–> inflamm and necrosis –> ulcers –> fistulas

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14
Q

where do anal fissures mostly occur

A

posterior midline of anal verge (decreased blood flow)

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15
Q

why is primaquine added

A

to get p ovale and vivax in liver (hypnozoites)- prevent relapses

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16
Q

which anemia has a positive acidified glycerol lysis test?

A

hereditary spherocytosis

spherocytes have increased fragility due to decreased surface area to volume ratio, so they lyse when in hypotonic saline

17
Q

adult women develop what sequlae from rubella

A

polyarthritis, polyarthalgia

18
Q

besides high fluid intake, high what can decrease calcium oxalate stones

A

citrate- binds free calcium

19
Q

which serological marker is most indicative of vertical transmission of hepatitis B?

A

HBeAg

20
Q

which enzyme converts NE to E?

A

PNMT in adrenal medulla

21
Q

cricothyrotomy incision passes through what

A

superficial cervical fascia
pretracheal fascia
cricothyroid membrane

22
Q

left atrial appendage susceptible to

A

thrombi formation

23
Q

osteoblastic mets

A

prostate
small cell lung cancer
hodgkin lymphoma

24
Q

osteoclastic mets

A
multiple myeloma
non-small cell lung cancer
non-hodgkin lymphoma
RCC
melanoma
25
Q

what should be monitored after evacuation of hyadtidiform moles

A

HCG

26
Q

adverse effects of mannitol

A

severe- pulm edema

HA, N/V
hypernatremia

27
Q

most common location of injury in thoracic aorta?

A

aortic isthmus (right after arch)

28
Q

rifiximin MOA in hepatic encephalopathy

A

nonabsorbable antibiotic that alters GI flora to decrease intestinal production and absorption of ammonia

29
Q

metaplasia in lungs from smoking

A

from columnar to squamous

30
Q

relative risk formula

A

a/(a+b) / c/(c+d)

31
Q

odds ratio formula

A

ad/bc

32
Q

which factor helps coronary blood flow autoregulation

A

NO and adenosine

33
Q

C1INH deficiency

A

no C1 inhibitor–> constituive cleave of C2 and C4 and no blocking kininogen–> bradykinin

–> bradykinin-associated angioedema