Vitamin K

Question 1

Naphthoquinone derivative w/ long isoprenoid side chain

Answer 1

Vitamin K

“Koagulation” vitamin

Question 2

Phylloquinone from dietary sources

Answer 2

Vitamin K1

Question 3

Menaquinone synthesized by bacterial flora

Answer 3

Vitamin K2

Question 4

Menadione: Synthetic, water soluble

Answer 4

Vitamin K3

Question 5

Function of Vitamin K

Answer 5

Required for POST-TRANSLATIONAL CARBOXYLATION OF glutamic acid (GAMMA CARBOXYLATION) – necessary binding to gamma carboxylated proteins

Question 6

Activates vitamin K

Answer 6

Epoxide reductase

Question 7

Coagulation factors that are vitamin K dependent

Answer 7

1972, C and S

Factors II, VII, IX, X
Protein C
Protein S

Question 8

Protein in bone

Answer 8

Osteocalcin

Question 9

Protein in kidney

Answer 9

Nephrocalcin - inhibitor of calcium oxalate stone formation

Question 10

Given in neonates at birth to PREVENT HEMORRHAGIC disease of the newborn

Answer 10

Vitamin K injection

Question 11

Vitamin K deficiency

Answer 11

Bleeding diathesis

Question 12

Vitamin K toxicity

Answer 12

Hemolysis –> hyperbilirubinemia –> KERNICTERUS (CNS DAMAGE)

Question 13

Newborns esp premature infants are particularly susceptible to Vitamin K deficiency d.t.

Answer 13

low fat stores

low breast milk levels of vitamin K

sterility of the infantile intestinal tract

liver immaturity

poor placental transport