Vitamin B3 (Niacin or Nicotinic Acid) Flashcards
1
Q
Active form of Niacin
A
Nicotinamide Adenine Dinucleotide (NAD)
Nicotinamide Adenine Dinucleotide Phosphate (NADP)
2
Q
Coenzyme role of Niacin
A
Oxidation Reduction Reactions
3
Q
Deficiency of Niacin
A
PELLAGRA dermatitis (photosensitive dermatitis) dementia diarrhea death
Casal’s Necklace
4
Q
Conditions associated with Pellagra like symptoms
A
Hartnup Disease - d.t. INTESTINAL MALABSORPTION and RENAL reabsorption of Tryptophan
Carcinoid Syndrome - overproduction of serotonin –> diversion of Tryptophan from NAD+ pathway
Vitamin B6 deficiency - defective KYNURENINASE that lead to defective synthesis of Niacin
5
Q
Common in people whose staple diet is Maize and Jowar
A
Pellagra
6
Q
Toxicity of Niacin
A
HEPATOTOXIC
PODAGRA
FACIAL FLUSHING
