Galactose Metabolism

Question 1

Phosphorylation of Galactose

Answer 1

Galactose –> Galactose 1-P

GALACTOKINASE

Question 2

Formation of UDP galactose

Answer 2

Galactose 1-P + UDP-glucose –> UDP-galactose + Glucose 1P

GALACTOSE 1-P URIDYL TRANSFERASE (GALT)

Question 3

Use of galactose as carbon source

Answer 3

UDP galactose –> UDP glucose

UPD-HEXOSE-4 EPIMERASE

Question 4

Rate Limiting Enzyme of Galactose Metabolism

Answer 4

GALACTOSE 1-P URIDYL TRANSFERASE (GALT)

Question 5

Mild symptoms

GALACTOSEMIA AND GALACTOSURIA

CATARACTS in EARLY CHILDHOOD

Answer 5

Galactokinase deficiency

Question 6

More severe symptoms

Galactosemia, galactosuria, cataracts, diarrhea, vomiting, jaundice

Poor growth in children, severe mental retardation and liver damage

Premature ovarian failure in females

Answer 6

CLASSIC GALACTOSEMIA

Galactose-1-phosphate-uridyl transferase deficiency

Question 7

Galactose is seen

Answer 7

Lactose
Glycolipids
Glycoproteins
GAG (Keratan sulfate)