Salvage Pathway and Purine Breakdown

Question 1

Enzymes in Salvage Pathway

Answer 1

Adenine phosphoribosyl-transferase (APRT)

Hypoxanthine guanine phosphoribosyltransferase (HGPRT)

Question 2

Drugs that act on purine salvage pathway

Answer 2

6 MP

Azathioprine

Question 3

Deficiency or dysfunction of ADA

Answer 3

Severe Combined Immunodeficiency Syndrome (SCID)

Question 4

X-linked disorder (only occurs in MALES) characterized by the ABSENCE of HGPRT

Answer 4

Lesch Nyhan Syndrome