Translation, Protein Synthesis and Modification (KING)

Question 1

Defines the set of rules (nucleotide triplets) by which information encoded within the genes is translated into proteins

Answer 1

GENETIC CODE

Question 2

Translational initiation complex composed of eIF-2 with GTP bound and inutuatir of methionine tRNA

Answer 2

TERNARY COMPLEX

Question 3

RNA mediated (ribozyme) enzymatic activity of the 60s ribosome that catalyzes transpeptidation during protein elongation

Answer 3

PEPTIDYLTRANSFERASES

Question 4

76 amino acid peptide enzymatically attached to proteins which in most cases targets the modified protein for degradation in the proteosome

Answer 4

UBIQUITIN

Question 5

Large protein complex whose function is to proteolytically degrade damaged or unneeded proteins

Answer 5

PROTEOSOME

Question 6

Bind to newly dissociated 40s ribosomal subunit

Allow translation initiation factor to associate with the 40s subunit

Answer 6

eIF 3 and eIF-1A

Question 7

Involved in the formation of BINARY complex of 40s preinitiation complex

Answer 7

eIF -2

primary target of ER STRESS RESPONSE

Question 8

CAP binding complex

important in 48s initiation complex

Answer 8

eIF-4F

Question 9

Hydrolysis of GTP bound to eIF-2 facilitates 60s association

Answer 9

eIF-5

Question 10

The most frequent cause of neonatal/early onset diabetes in patients with CONSANGUINEOUS parents

Answer 10

WOLCOTT-RALLISON SYNDROME (WRS)

Question 11

Translation factor responsible for engaging the CAP STRUCTURE of mRNA

Answer 11

eIF 4F

• eIF 4E
• eIF 4A
• eIF 4G

Question 12

Protein that would normally be targeted for MTOR mediated regulation in the absence of rapamycin

Answer 12

eIF-4E

Question 13

Translation factor that is the target of an interferon mediated translational control mechanism

Answer 13

eIF-2

Question 14

Function of eIF-2B

Answer 14

in order for additional rounds of translational initiation to occur, the GDP bound to eIF 2 must be exchanged for GTP

Question 15

Translation factor that contains modified amino acid (DIPHTHAMIDE) recognized by a toxin produced by Diphtheria

Answer 15

eEF-2

Question 16

Has a chemical structure that resembles an aminoacyl-tRNA

(-) with peptide transfer resulting in premature termination in both prokaryotes and eukaryotes

Answer 16

PUROMYCIN

Question 17

Involved in the prevention of aggregation and improper folding of newly synthesized proteins

Answer 17

CHAPERONES

Question 18

Proteins or complexes involved in proteins synthesis which exhibits peptidyltransferase activity

Answer 18

RIBOSOME

Question 19

Synthesis of all proteins in both prokaryotic and eukaryotic cells begins in which amino acid

Answer 19

METHIONINE

Question 20

Determines the SEQUENCE of a polypeptide synthesized by the polyribosome complex

Answer 20

mRNA