Fructose Metabolism

Question 1

Phosphorylation of fructose

Answer 1

Fructose –> Fructose 1-P

FRUCTOKINASE or HEXOKINASE

Question 2

Formation of DHAP and Glyceraldehyde

Answer 2

Fructose 1-P –> DHAP + Glyceraldehyde

ALDOLASE B

Question 3

Benign and asymptomatic

Answer 3

Essential Fructokinase

Fructokinase deficiency

Question 4

Profound hypoglycemia and vomiting after consumption of fructose or sucrose

Jaundice, hemorrhage, hepatomegaly, and liver failure

Renal dysfunction, hyperuricemia, lactic acidosis and death

Symptoms appear after weaning from milk

Answer 4

Hereditary Fructose Intolerance

Aldolase B Deficiency