Glycosaminoglycans Flashcards by Jamaira Belmes

Q

Present in bacteria and ECM of nearly all animals

for CELL MIGRATION during morphogenesis and WOUND REPAIR

A

HYALURONIC ACID

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Q

Major component of CARTLAGE

A

Chondroitin sulfate

cartilage
bone
CNS

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Q

Isolated from CORNEA

A

KERATAN SULFATE I

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Q

Isolated from CARTILAGE

A

KERATAN SULFATE II

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Q

Play a critical role in CORNEAL TRANSPARENCY

A

KERATAN SULFATE I and II

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Q

Consists of glucosamine and 2 uronic acids

Anticoagulant

Binds to Lipoprotein Lipase

A

HEPARIN

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Q

Present on many cell surfaces as proteoglycan

act as RECEPTORS

cell growth and cell to cell communication

KIDNEY BASEMENT MEBRANE

CHARGE SELECTIVENESS OF GLOMERULAR FILTRATION

A

HEPARAN SULFATE

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Q

Widely distributed GAG

The MAIN GAG of skin

A

Dermatan sulfate

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Q

GAG with NO uronic acid

A

Keratan Sulfate

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Q

GAG with NO sulfate group

A

Hyaluronic Acid

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Q

GAG NOT covalently linked to protein

A

Hyaluronic Acid

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Q

GAG found in BACTERIA

A

Hyaluronic Acid

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Q

GAG which is an ANTICOAGULANT

A

HEPARIN

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Q

MOST ABUNDANT GAG

A

Chondroitin sulfate

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Q

Site of Synthesis of GAG

A

Endoplasmic Reticulum

Golgi

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Q

Shape of Proteoglycan Monomer

A

Bottle Brush

Q

GAG that helps in CELL MIGRATION

A

Hyaluronic Acid

Q

GAG that have a role in compressibility of cartilage in weight bearing

A

Hyaluronic Acid

Chondroitin Sulfate

Q

GAGs that play a role in CORNEAL TRANSPARENCY

A

Keratan Sulfate I

Dermatan Sulfate

Q

Majority of GAGs are EXTRACELLULAR

EXAMPLES of Intracellular GAGs

A

Heparin - mast cells

Heparan sulfate - synaptic and other vesicles