Glycosaminoglycans Flashcards

1
Q

Present in bacteria and ECM of nearly all animals

for CELL MIGRATION during morphogenesis and WOUND REPAIR

A

HYALURONIC ACID

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2
Q

Major component of CARTLAGE

A

Chondroitin sulfate

cartilage
bone
CNS

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3
Q

Isolated from CORNEA

A

KERATAN SULFATE I

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4
Q

Isolated from CARTILAGE

A

KERATAN SULFATE II

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5
Q

Play a critical role in CORNEAL TRANSPARENCY

A

KERATAN SULFATE I and II

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6
Q

Consists of glucosamine and 2 uronic acids

Anticoagulant

Binds to Lipoprotein Lipase

A

HEPARIN

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7
Q

Present on many cell surfaces as proteoglycan

act as RECEPTORS

cell growth and cell to cell communication

KIDNEY BASEMENT MEBRANE

CHARGE SELECTIVENESS OF GLOMERULAR FILTRATION

A

HEPARAN SULFATE

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8
Q

Widely distributed GAG

The MAIN GAG of skin

A

Dermatan sulfate

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9
Q

GAG with NO uronic acid

A

Keratan Sulfate

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10
Q

GAG with NO sulfate group

A

Hyaluronic Acid

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11
Q

GAG NOT covalently linked to protein

A

Hyaluronic Acid

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12
Q

GAG found in BACTERIA

A

Hyaluronic Acid

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13
Q

GAG which is an ANTICOAGULANT

A

HEPARIN

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14
Q

MOST ABUNDANT GAG

A

Chondroitin sulfate

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15
Q

Site of Synthesis of GAG

A

Endoplasmic Reticulum

Golgi

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16
Q

Shape of Proteoglycan Monomer

A

Bottle Brush

17
Q

GAG that helps in CELL MIGRATION

A

Hyaluronic Acid

18
Q

GAG that have a role in compressibility of cartilage in weight bearing

A

Hyaluronic Acid

Chondroitin Sulfate

19
Q

GAGs that play a role in CORNEAL TRANSPARENCY

A

Keratan Sulfate I

Dermatan Sulfate

20
Q

Majority of GAGs are EXTRACELLULAR

EXAMPLES of Intracellular GAGs

A

Heparin - mast cells

Heparan sulfate - synaptic and other vesicles