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Biochemistry > Bilirubin Metabolism (Heme Catabolism) > Flashcards

Bilirubin Metabolism (Heme Catabolism) Flashcards

1
Q

Biliverdin to Bilirubin

A

BILIVERDIN REDUCTASE

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2
Q

Formation of Bilirubin Diglucoronide

A

bilirubin is conjugated to 2 molecules of GLUCURONIC ACID

BILIRUBIN GLUCURONYLTRANSFERASE - deficient in Crigler Najjar I and II and Gilbert Syndrome

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3
Q

Conditions that increase INDIRECT bilirubin

A 
Hemolysis
Crigler Najar Syndrome
Gilbert Syndrome
Decrease levels of conjugation enzymes in newborn
Hepatic Damage
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4
Q

Conditions that INCREASE DIRECT (CONJUGATED) bilirubin

A

Hepatic Damage
Bile Duct Obstruction (clay colored stool)
Dubin Johnson (black pigmentation of the liver)
Rotor Syndrome

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5
Q

Chemical method to estimate bilirubin in serum

A

VAN DEN BERGH TEST

reddish purple azopigment is formed
540 nm

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Biochemistry (75 decks)

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