Lipogenesis

Question 1

Synthesis of fatty acids (PALMITATE)

Answer 1

Lipogenesis (Fatty Acid Synthesis)

Question 2

Site of Fatty Acid Synthesis

Answer 2

Liver, kidney, brain, lung , mammary gland, adipose tissue

Question 3

Substrate of Fatty Acid Synthesis

Answer 3

Acetyl CoA

Question 4

Rate Limiting Step of Fatty Acid Synthesis

Answer 4

Acetyl CoA + HCO3 + ATP –> Malonyl CoA

ACETYL COA CARBOXYLASE

Question 5

Motochondrial acetyl CoA (from oxidation of pyruvate) is transported to the cytosol using

Answer 5

CITRATE SHUTTLE

Question 6

Activates Acetyl CoA

Rate Limiting Step of Lipogenesis

Answer 6

Acetyl CoA Carboxylase

COENZYME: Biotin

Question 7

Activate Acetyl CoA Carboxylase

Answer 7

CITRATE and INSULIN

Question 8

Inhibit Acetyl CoA Carboxylase

Answer 8

GLUCAGON and EPINEPHRINE

Question 9

Large, Multienzyme Complex in the CYTOPLASM

Induced in the liver AFTER a meal by high carbohydrates

Answer 9

Fatty Acid Synthase (Palmitate Synthase)

+) acyl carrier protein (ACP) that requires VIT B5 (PANTOTHENIC ACID