Vitamin B1 (Thiamine)

Question 1

Also called Thiamine (B1)

Answer 1

Aneurine

Question 2

Active form of Thiamine

Answer 2

Thiamine Pyrophosphate (Thiamine Diphosphate)

Question 3

Coenzyme role of Thiamine Pyrophosphate

Answer 3

DECARBOXYLATION reaction of alpha keto acids and branched amino acids

Pyruvate dehydrogenase
Alpha ketoglutarate dehydrogenase
Branched chain ketoacid dehydrogenase
Trans Ketolase

Question 4

Deficiency of Vitamin B1 (Thiamine)

Answer 4

WET BERIBERI - high output cardiac failure

DRY BERIBERI - peripheral and central nervous system

Wernicke’s Encephalopathy (reversible) - confusion, ophthalmoplegia, ataxia

Korsakoff Encephalopathy (irreversible) - dementia, confabulation

Question 5

Biochemical assessment of thiamin deficiency

Answer 5

Reduced Erythrocyte Transketolase activity

Urinary Thiamine Excretion

Question 6

Acute life threatening neurologic condition

Answer 6

Wernicke’s Encephalopathy

Question 7

Amnestic disorder d.t. chronic alcohol consumption

Answer 7

Korsakoff Encephalopathy

Question 8

Combination of Wernicke encephalopathy and Korsakoff syndrome

Answer 8

Wernicke-Korsakoff syndrome

-damage to MEDIAL DORSAL NUCLEUS of THALAMUS, MAMMILLARY BODIES

Question 9

Vitamin deficiency that can cause LACTIC ACIDOSIS

Answer 9

Thiamine

Question 10

Thiamine requirement increases in excessive intake of

Answer 10

Carbohydrate