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Biochemistry > Topnotch - Genesis > Flashcards

Topnotch - Genesis Flashcards

1
Q

Components of nucleotide

A

phosphate group
nitrogenous base
sugar

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2
Q

Drug Induced Lupus

A 
methyldopa
sulfa drugs
hydralazine
isoniazid
procainamide
phenytoin
etanercept
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3
Q

Histones are rich in

A

lysine

leucine

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4
Q

Rate limiting enzyme of de novo purine synthesis

A

glutamine PRPP amidotransferase

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5
Q

Can cause SCID

A

adenosine deaminase (ADA) deficieny

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6
Q

Metabolizes Azathioprine and 6 MP

A

Xanthine oxidase

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7
Q

Rate limiting enzyme in PYRIMIDINE synthesis

A

CPS II

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8
Q

Orotic aciduria treatment

A

Uridine

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9
Q

Lactose

A

galactose + glucose

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10
Q

Sucrose

A

fructose + glucose

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11
Q

Sites of Na dependent entry of glucose

A

intestinal epithelium

renal tubules

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12
Q

GLUT 1

A

brain

RBC

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13
Q

GLUT 4

A

fat tissue

skeletal muscle

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14
Q

Rate limiting enzyme GLYCOLYSIS

A

PFK1

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15
Q

PFK 1 (-)

A

citrate

ATP

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16
Q

PFK1 inducers

A

AMP

fructose 2,6 bisphophate

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17
Q

Activates pyruvate kinase

A

fructose 1,6 bisphosphate

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18
Q

(-) pyruvate kinase

A

ATP

alanine

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19
Q

Form of cholesterol in chylomicrons

A

cholesteryl ester

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20
Q

Cells that synthesizes chylomicrons

A

enterocytes

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21
Q

Packaged inside chylomicrons

A

TGL
cholesteryl esters
vit ADEK

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22
Q

Synthesize HMG-CoA

A

HMG-CoA synthase

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23
Q

Enzyme in cholesterol synthesis inhibited by statin

A

HMG-CoA reductase

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24
Q

Lipoproteins that deliver CHOLESTEROL and TGL to the body

A

VLDL

HDL

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25
Q

Apoproteins on HDL

A

apo I
apo C-II
apo E

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26
Q

Apoproteins on HDL that are donated to other lipoproteins

A

apo C-II

apo E

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27
Q

LCAT function

A

esterifies cholesterol

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28
Q

Apoproteins on VLDL

A

apo B100
apo CII
apo E

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29
Q

Remove TGL from VLDL

A

lipoprotein lipase

CETP

30
Q

Remove TGL from IDL

A

hepatic lipase

CETP

31
Q

HDL is a repository for which apolipoprotein

A

apo C-II

apo E

32
Q

Must be present for GKRP to inactivate glucokinase

A

F6P

33
Q

Enzyme that commits glucose to glycolysis

A

PFK1

34
Q

Inhibited by alanine in glycolysis

A

pyruvate kinase

35
Q

Most affected by pyruvate kinase deficiency

A

RBC

36
Q

Intermediate in the conversion of pyruvate to PEP in gluconeogenesis

A

OAA

37
Q

Converts pyruvate to OAA in gluconeogenesis

A

pyruvate carboxylase

38
Q

Converts OAA to PEP in gluconeogenesis

A

PEP carboxykinase

39
Q

Cofactor of pyruvate carboxylase

A

ATP
Biotin
CO2

40
Q

Cofactor required by PEP carboxykinase

A

GTP

41
Q

Biotin is cofactor for which enzymes

A

pyruvate carboxylase
acetyl CoA carboxylase
propionyl CoA carboxylase

42
Q

Rate limiting for gluconeogenesis

A

FBPase I

43
Q

Location of glucose 6 phosphatase

A

liver

kidney

44
Q

Organelle where glucose 6 phosphatase is active

A

ER

45
Q

Glycogen is most abundant

A

muscle

liver

46
Q

Lysosomal enzyme that converts glycogen to glucose

A

alpha 1,4 glucosidase

47
Q

Produced by glycogen phosphorylase

A

G1P

48
Q

Enzymes that glucagon phosphorylates

A

glycogen phosphorylase

glycogen synthase

49
Q

Von Gierke Treatment

A

frequent cornstarch ingestion b/w meals

avoidance of fructose and galactose

50
Q

MC cause of death in Pompe disease

A

HF (hypertrophic cardiomyopathy)

51
Q

Glycogen storage disease presents in adolescence or early adulthood

myoglobinuria AFTER exercise

A

Mc Ardle disease

52
Q

Genetic inheritance of Glycogen storage diseases I - IV

A

autosomal recessive

53
Q

Accumulation of limit dextrins in cytosol

A

Cori disease - debranching enzyme deficiency

54
Q

Converts G6P to phosphogluconolactone

A

G6PD

55
Q

Storage molecule produced through the action of G6PD

A

NADPH

56
Q

Produced at the end of the oxidative portion of HMP shunt

A

ribulose 5 phosphate
2 NADPH
CO2

57
Q

G6PD deficiency

A

x-linked recessive

58
Q

PBS finding in G6PD deficiency

A

Heinz bodies (bite cells)

59
Q

Anti malarial that can precipitate G6PD deficiency

A

Primaquine

Quinidine

60
Q

Location of HMP shunt

A

cytosol

61
Q

Enzyme in HMP shunt that requires thiamine as cofactor

A

transketolase

62
Q

Enzyme in respiratory burst that requires NADPH as cofactor

A

NADPH oxidase

63
Q

Rate limiting enzyme in the oxidative part of HMP shunt

A

G6PD

64
Q

Carbohydrates taken up into the enterocytes by SGLT1 transporter

A

glucose

galactose

65
Q

Clinical presentation of essential fructosuria

A

fructose in blood and urine

66
Q

Cofactors for pyruvate dehydrogenase complex

A 
thiamine
lipoic acid
CoA
FAD
NAD
67
Q

Symptoms of Dry Beriberi

A

polyneuropathy

symmetrical muscle wasting

68
Q

Symptoms of Wet Beriberi

A

tachycardia
high output HF
edema

69
Q

Poison that (-) lipoic acid

A

arsenic

70
Q

PDH complex deficiency

A

x-linked recessive

71
Q

Purely ketogenic AA

A

leucine

lysine

72
Q

Disorders of thiamine deficiency

A

Beriberi

Wernicke-Korsakoff syndrome

Biochemistry (75 decks)

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