Viral Disease of Lower Resp System-Influenza Flashcards
Influenza Symptoms
Chills, fever, headache, and muscle aches
enveloped single stranded RNA virus, w/ 8 RNA segments which contain 1 or 2 genes
Influenza A
Two kinds of glycoprotein SPIKES embedded in Influenza A
Hemagglutinin (HA) and Neuraminidase (NA)
Spikes used for attachment to host cells
HA! Hemagglutinin (16 subtypes)
Spikes used to release virus from cell
NA! Neuraminidase ~9 Subtypes~
major changes that result from reassortment different strains of a virus or different viruses
antigenic shift
Minor changes that occur naturally in influenza virus antigens as a result of mutation
antigenic drift
Antigenic shifts in influenza A caused by
changes in HA & NA spikes (proteins)
Antigenic drifts in influenza likely caused by
point mutations in genes encoding for HA/ NA spikes