Chap 15- B cells and Humoral Immunity Flashcards
These cells work well against free circulating antigens such as free viruses and microbes
B cells/ humoral immunity
antibodied mediated immunity involves ____ and is also know as
B cells; humoral immunity
immunity that eliminates microbial invaders in the blood/ tissue fluids
humoral immunity
What do B cells produce ONCE ACTIVATED?
Y shaped proteins called antibodies, that bind to antigens and mark them to be eliminated
How are antibodies involved in Humoral immunity?
B cells produce antibodies, which binds & tag antigens for later destruction
How are B cells activated?
B cell receptor binds to antigen, processes it and presents it to TH cells. If T helper cell recognizes antigen, it activates B cell, allowing it to undergo clonal expansion
What happens when B cells divide (clonal expansion) once activated?
it produces daughter cells and secretes antibodies
The daughter cells produced by clonal expansion both ______
recognize the same epitopes as the B cell they originate from
daughter cell produced by clonal expansion that produces antibody
plasma cells
daughter cell produced by clonal expansion that are long lived cells and are responsible for enhanced secondary response
memory cells
B cell activation requires assistance ______
from T helper cells
What do B cells carry on their surfaces?
immunoglobins/antibodies
Once T cell recognizes MHC, it can
activate B cell
What Ig is known as the B cell receptor?
IgD
Host cell surface proteins that present antigen to T cells
MHC- major histocompatibility complex
How do B cells recognize and bind to antigens?
B cells contain B cell receptors that recognize and bind to specific epitope on antigen
Molecule on a T cell that enables the T cell to recognize a specific antigen
T cell receptor
Major difference between BCR and TCR
BCR are able to recognize FREE antigens
TCR can only recognize antigens presented w/ a MHC
Protective Mechanisms of binding antigens to antibodies
Agglutination, Activation of complement, Antibody dependent cell mediated Cytotoxicity, Opsonization, Neutralization
protective mechanism that reduces # of infectious agents to be dealt with; binding to multiple cells to immobilize them
agglutination
protective mechanism that blocks adhesion of bacteria/viruses to mucosa; Where antibodies mask pathogenic portion of antigens
Neutralization
protective mechanism where Abs attached to target cells cause destruction via macrophages, eosinophils, and NK cells
Antibody dependent cell mediated cytotoxicity
protective mechanism that causes inflammation and cell lysis
activation of complement
protective mechanism that coats antigen w/ Ab to enhance phagocytosis
opsonization
Do antibodies require MHC to recognize antigens?
no, t cells receptors require MHC.
