Chap 15- B cells and Humoral Immunity

Question 1

These cells work well against free circulating antigens such as free viruses and microbes

Answer 1

B cells/ humoral immunity

Question 2

antibodied mediated immunity involves ____ and is also know as

Answer 2

B cells; humoral immunity

Question 3

immunity that eliminates microbial invaders in the blood/ tissue fluids

Answer 3

humoral immunity

Question 4

What do B cells produce ONCE ACTIVATED?

Answer 4

Y shaped proteins called antibodies, that bind to antigens and mark them to be eliminated

Question 5

How are antibodies involved in Humoral immunity?

Answer 5

B cells produce antibodies, which binds & tag antigens for later destruction

Question 6

How are B cells activated?

Answer 6

B cell receptor binds to antigen, processes it and presents it to TH cells. If T helper cell recognizes antigen, it activates B cell, allowing it to undergo clonal expansion

Question 7

What happens when B cells divide (clonal expansion) once activated?

Answer 7

it produces daughter cells and secretes antibodies

Question 8

The daughter cells produced by clonal expansion both ______

Answer 8

recognize the same epitopes as the B cell they originate from

Question 9

daughter cell produced by clonal expansion that produces antibody

Answer 9

plasma cells

Question 10

daughter cell produced by clonal expansion that are long lived cells and are responsible for enhanced secondary response

Answer 10

memory cells

Question 11

B cell activation requires assistance ______

Answer 11

from T helper cells

Question 12

What do B cells carry on their surfaces?

Answer 12

immunoglobins/antibodies

Question 13

Once T cell recognizes MHC, it can

Answer 13

activate B cell

Question 14

What Ig is known as the B cell receptor?

Answer 14

IgD

Question 15

Host cell surface proteins that present antigen to T cells

Answer 15

MHC- major histocompatibility complex

Question 16

How do B cells recognize and bind to antigens?

Answer 16

B cells contain B cell receptors that recognize and bind to specific epitope on antigen

Question 17

Molecule on a T cell that enables the T cell to recognize a specific antigen

Answer 17

T cell receptor

Question 18

Major difference between BCR and TCR

Answer 18

BCR are able to recognize FREE antigens

TCR can only recognize antigens presented w/ a MHC

Question 19

Protective Mechanisms of binding antigens to antibodies

Answer 19

Agglutination, Activation of complement, Antibody dependent cell mediated Cytotoxicity, Opsonization, Neutralization

Question 20

protective mechanism that reduces # of infectious agents to be dealt with; binding to multiple cells to immobilize them

Answer 20

agglutination

Question 21

protective mechanism that blocks adhesion of bacteria/viruses to mucosa; Where antibodies mask pathogenic portion of antigens

Answer 21

Neutralization

Question 22

protective mechanism where Abs attached to target cells cause destruction via macrophages, eosinophils, and NK cells

Answer 22

Antibody dependent cell mediated cytotoxicity

Question 23

protective mechanism that causes inflammation and cell lysis

Answer 23

activation of complement

Question 24

protective mechanism that coats antigen w/ Ab to enhance phagocytosis

Answer 24

opsonization

Question 25

Do antibodies require MHC to recognize antigens?

Answer 25

no, t cells receptors require MHC.