Chap 20- Antibacs - Target cell wall synthesis

Question 1

Meds that target cell wall synthesis (BaGa-B)

Answer 1

B-Lactam & Glycopeptide antibiotics, Bacitracin

Question 2

How does BaGa-B affect cell wall synthesis?

Answer 2

They interfere with peptidoglycan synthesis, which weakens bacterial cell wall and may cause cell to burst

Question 3

Group of antibiotics that inhibit peptidoglycan synthesis; all have shared chemical structure called a β-lactam ring (PCCM)

Answer 3

B-Lactam antibiotics penicillin is the beyonce of this med group

Question 4

Medications that target cell wall synthesis (Ba.Ga-B) are typically only effective against _____? why

Answer 4

growing bacterial cells bc they’re continuously producing peptidoglycan

Question 5

How do B lactam antibiotics interfere w/ peptidoglycan synthesis?

Answer 5

they attack Penicillin binding proteins (PBP), that are responsible for synthesizing peptidoglycan that form bacterial cell wall structure

Question 6

B lactam bacterias are preferred to treat bacterial infections because

Answer 6

they have a HIGH therapeutic index

Question 7

** TARGET FOR B LACTAM ANTIBIOTICS **

Answer 7

Penicillin Binding Proteins!!! (PBPs)

Question 8

B lactam antibiotics have a shared _______, but all different in their _____

Answer 8

shared B lactam ring; differ in their R groups; (side chains are what is chemically altered to create derivatives)

Question 9

Penicillin work better on gram _________ bacterias? Why?

Answer 9

Gram positive, because of its peptidoglycan layer outside of cell wall, penicillin can inhibit peptidoglycan production & target its cell wall synthesis / weakening the cell wall

Question 10

How does penicillin prevent cross linking of peptidoglycan?

Answer 10

by binding to Penicillin Binding Proteins

Question 11

Target of β-lactam antimicrobial medications; their role in bacteria is peptidoglycan synthesis.

Answer 11

PBPs!!! Penicillin Binding Proteins

Question 12

enzymes produced by bacteria that break open b lactam ring, and inactivate b lactam meds

Answer 12

b lactamases

Question 13

penicillins that act against Gram Positive and Gram Negatives; INACTIVATED by b lactamase

Answer 13

Broad spectrum penicillins

Question 14

penicillins with reduced activity against gram positive and DESTROYED by b lactamases

Answer 14

extended spectrum penicillins

Question 15

Penicillin + B lactamase inhibitor

Answer 15

includes inhibitor to protect penicillin (Augmentin)

Question 16

Other B lactam antibiotic PCCM

Answer 16

Penicillin** Cephlasporins, Carbapenems, Monobactum

Question 17

polypeptide antibiotic that Interferes with the synthesis of linear strands of peptidoglycans; topical application only; effective against gram + and -

Answer 17

Bacitracin

Question 18

most common used glycopeptide antibiotic; that Prevents the cross-linking of peptidoglycan​ by binding to amino acid side chain of NAM molecules

Answer 18

vancomycin