Chap 16- Infectious Diseases & Koch's postulates Flashcards
Establishment and multiplication/growth of a microorganism on a surface
colonization
Colonization by a pathogen on or within the body
infection
An infection can be subclinical, meaning
it may cause no symptoms/mild symptoms
An infection that results in disease and prevents the body from functioning normally
infectious disease
subjective effects that are experienced by patient (pain/nausea)
symptoms
objective evidence of infection (can be seen & measured)
signs
Infection in a previously healthy individual; initial infection
primary infection
Infection that occurs along with or immediately following another infection
secondary infection
microbe/virus that cause disease in otherwise healthy person
primary pathogen
microbes that causes disease only when body is immune systems are compromised
oppurtunistic pathogen
ability of a pathogen to overcome body defenses and cause disease; degree of pathogenicity
virulence
Traits of a microbe that promote pathogenicity
virulence factors
infectious diseases that spread from one host to another
communicable/ contagious
Number of microbes sufficient to establish an infection
infectious dose
time between infection to host & onset of signs/symptoms
incubation period
signs and symptoms of disease
illness
Period of recuperation and recovery from an illness
convalescence
Progression/ Stages of Infectious Disease
Incubation, illness, convalescence
A period of early, vague symptoms indicating the onset of a disease
prodromal phase
infectious agents can be spread mostly through which 2 phases
incubation & convalescence
may harbor and spread infectious agent for long periods of time in absence of signs or symptoms
carriers
infection where symptoms develop quickly, last a short time (ex: strep throat); incubation –> illness —> convalescence
Acute infection
infection that generally develops slowly and lasts for months or years; incubation—->illness
chronic infection
Infection in which the infectious agent is present but not causing symptoms. incubation —> illness —>convalescence —> latency —> recurrence
latent infection (ex: tuberculosis, herpes)
Infection limited to one site in or on the body
localized infection
Infection in which the infectious agent spreads throughout the body
systemic infection
bacteria circulation in blood
bacteremia
toxins circulating in bloodstream
toxemia
viruses circulating in bloodstream
viremia
criteria used to determine the cause of an infectious disease by culturing the agent and reproducing the disease
Koch’s postulates
Koch’s Postulates 1-5
- Microorg must be present in every case of disease 2. Microorg must be grown in pure culture from diseased host 3. Same diseases can be produced when a pure culture can of microrg is introduced into new host 4. Microorg must be recovered from experimental host
Limitation of Koch’s Postulates
some orgs cannot be grown in lab, infected ppl dont always have symptoms, suitable animal host not always available for experiment
criteria established to study a microbe’s virulence factors using genetic and molecular techniques
Molecular Koch’s Postulates