Chap 16- Pathogenesis & Establishing Infection Flashcards
Human body is beneficial to microbes bc _____
microbes see human body as a rich source of nutrients
manner in which disease develops
pathogenesis
Mechanisms of pathogenesis
production of toxins that are then ingested, colonization of mukemembranes , then toxins are produced, invasion of host tissues to avoid defenses and produce toxins
For a pathogen to be successful, it must
overcome host defenses long enough to multiply & exit; if pathogen overwhelms host, it may kill it
Pathogen become less virulent , as host becomes less suspectible
Pathogen and host evolve towards balanced pathogenicity
what bacteria uses to attach to hosts
adhesins
molecule to which an adhesin attaches to
receptor
________ dictates type of cell to which bacterium can attach
Adherence
microorganism must multiply in order to colonize host; in order to colonize pathogen must deal w/ host defenses; must compete with normal microbiota
colonization
in order for microbe to colonize, it must avoid ???
Secretory IgA
Iron-binding substance produced by bacteria to scavenge iron
siderophore
What do some Gram negative cells do?
deliver molecules (effector proteins) directly into host cell using secretion systems
Mechanism that allows bacteria to transfer gene products directly into hosts cells
type 3 secretion system/ injectisome
What do the effector proteins do to host cell?
They induce changes (like alters cells cytoskeleton structure) or to direct host cell to engulf bacteria
When pathogens penetrate anatomical barriers _______
invasion
