Treatment: Antidepressant Drugs Flashcards

1
Q

what are the 4 drug classes?

A

SSRI’s, TCAs, MAOIs, Novel or Duel

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2
Q

these classes of drugs normalize levels of what in the brain?

A

serotonin, dopamine and norepinephrine, thus, their neurotransmission at the synapse

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3
Q

what is synaptic pruning?

A

when connections between nerve cells are not used, nerve cells atrophy and volume decreases

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4
Q

why does antidepressant response take days to weeks?

A

bc it requires sufficient time for the levels of BDNF to gradually rise an exert synaptic and nerve cell sprouting

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5
Q

antidepressants increase what?

A

BDNF and effect synaptic plasticity by increasing the activity of neurotransmitters in the synapse
- may also increase synaptic sprouting of rewiring of connections which are dysregulated at the synapse

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6
Q

when do the clinical antidepressant effects start to occur?

A

only after chronic admin of days to weeks

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7
Q

when Tx begins, what happens with connections?

A

they are used and formed and Bain volume in the areas implicated in depression increase

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