Limbic System - neurophysiology of symptoms

Question 1

how does the limbic system communicate?

Answer 1

higher and lower brain centres communicate with the limbic system to link thoughts and autonomic NS responses to emotions

Question 2

what is the role of the neocortex and hippocampus ?

Answer 2

mediate cognitive aspects of depression, such as memory impairments and feelings of worthlessness, hopelessness, guilt, doom and suicidality

Question 3

what are the active neurotransmitters in the limbic system?

Answer 3

serotonin, norepinephrine and dopamine

Question 4

what is the limbic system made up of?

Answer 4

hippocampus, parahippocampal gyrus, cingulate gyrus, amygdala, and the fornix (a bridge like structure which connects the hippocampus with the hypothalamus)

Question 5

dysregulation and neuroanatomical changes in the hypothalamus are responsible for:

Answer 5

neurovegetative symptoms of depression including too much or too little sleep, appetite and energy, loss of interest in sex and other pleasurable activities

Question 6

limbic system and basal ganglia are involved in the development of what?

Answer 6

mood disorders

Question 7

what happens when there is a dysregulation in the active neurotransmitters?

Answer 7

• they are no longer able to do their job well
• causes over activity of the amygdala
• results in abnormality of connectivity within limbic system an may explain symptoms of emotional liability, irritability and suicidality