Genetic Predisposition - Brain Derived Neurotrophic Factor Flashcards
BDNF is not only related to depression, it is also related to?
multiple psychiatric disorders
the ability of the serotonin system to adapt and change in response to various stimuli is influenced by what?
BDNF, all throughout life
during brain development, the cyclic process promotes what?
outgrowth, synapse formation and survival of serotonin neurons and the eventual interventions of multiple brain regions
activation of serotonin receptors stimulate the expression of what?
BDNF factor gene
BDNF may be the link between what?
stress, neurogenesis and hippocampal atrophy in depression
what is BDNF?
is a growth factor (protein found high in concentrations in brain) that plays major role in birth, survival and maturation of brain cells during development
what is BDNF important for?
neuronal cell growth as well as the synaptic changes that occur through a persons life
how does BDNF contribute to these processes?
activates DNA-binding factors that stimulate the genes involved in serotonin function, such as serotonin transporter and tryptophan hydrolase, the serotonin synthesizing enzyme
do people with MDD have higher or lower levels of BDNF?
lower