Genetic Predisposition - Brain Derived Neurotrophic Factor Flashcards

1
Q

BDNF is not only related to depression, it is also related to?

A

multiple psychiatric disorders

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2
Q

the ability of the serotonin system to adapt and change in response to various stimuli is influenced by what?

A

BDNF, all throughout life

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3
Q

during brain development, the cyclic process promotes what?

A

outgrowth, synapse formation and survival of serotonin neurons and the eventual interventions of multiple brain regions

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4
Q

activation of serotonin receptors stimulate the expression of what?

A

BDNF factor gene

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5
Q

BDNF may be the link between what?

A

stress, neurogenesis and hippocampal atrophy in depression

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6
Q

what is BDNF?

A

is a growth factor (protein found high in concentrations in brain) that plays major role in birth, survival and maturation of brain cells during development

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7
Q

what is BDNF important for?

A

neuronal cell growth as well as the synaptic changes that occur through a persons life

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8
Q

how does BDNF contribute to these processes?

A

activates DNA-binding factors that stimulate the genes involved in serotonin function, such as serotonin transporter and tryptophan hydrolase, the serotonin synthesizing enzyme

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9
Q

do people with MDD have higher or lower levels of BDNF?

A

lower

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