Systemic Inflammation Flashcards

1
Q

first, systemic manifestations and co morbidities are the result of what?

A

“spill over” of the inflammatory and respiratory events occurring in the lungs

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2
Q

second, the pulmonary manifestations are simply one form expression of what state?

A

“systemic” inflammatory state where there is multiple organ comprimise

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3
Q

in the first view, how should therapies be used?

A

therapies should be primarily directed to the lungs

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4
Q

in the second view, how should therapies be used?

A

therapies should be shifted to the systemic inflammatory state

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5
Q

where are most treatments directed to?

A

the lungs

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6
Q

when is systemic inflammation increased?

A

during exacerbations and is associated with a decline in lung function

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7
Q

what cytokines have been linked to muscle weakness, skeletal muscle atrophy or cachexia?

A

IL-1 beta, IL-6, TNF-alpha, and chemokines

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8
Q

all cytokines except what, have increased plasma concentrations?

A

IL-1 beta

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9
Q

what is leptin?

A

is an adipokine derived from fat cells
- regulates energy balance

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10
Q

is leptin increased or decreased in patients with COPD?

A

it is decreased

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