Pharmacologic Therapy Flashcards
what are the long term control medications?
- inhaled corticosteroids
- long acting beta 2 agonist
- leukotriene modifiers
- systemic corticosteroids
- mast cell stabilizers
- monoclonal antibody
what are the quick relief medications?
- beta 2 agonist
- anticholinergic
- systemic corticosteroids
medications are separated into what 2 categories?
- long term control medications that address inflammation and airway obstruction
- quick relief medications that reverse acute airflow obstruction
all medications are given through inhalation except?
monoclonal antibody meds which are given SQ
what is the function of beta 2 agonists (ex. salbutamol)?
act on the adrenergic receptors of airway smooth muscle, thereby increasing the levels of cyclic AMP and promoting muscle relaxation
what is the function of anticholinergic receptors (ex. Ipratropium)?
inhibit muscarinic cholinergic receptors to reduce vagal tone resulting in bronchodilation
what is the function of systemic corticosteroids?
block the production of inflammatory mediators derived from the cyclooxygenase and lipoxygenase pathways
what is the mechanism of action for corticosteroids?
is to decrease inflammation by suppression of polymorphonuclear leukocytes and fibroblasts and reducing capillary permeability
what is the function of leukotriene modifiers?
it interferes with the action of leukotrienes
what is the function of mast cell stabilizers?
prevent the release of inflammatory mediators such as histamine from sensitized mast cells after an antigen-IgE interaction has occured
what is the function of a monoclonal antibody therapy (ex. Xolair)?
binds to an inactivates endogenous IgE antibodies to prevent basophil and mast cell sensitization
when should u decide to take inhaled short acting corticosteroids?
those with symptoms of asthma that occur more than 2 days per week
what is the preferred quick relief medication?
beta 2 agonist
what quick relief medication is used as an “add on” therapy?
anticholinergic medications
