Tranexamic Acid TXA Flashcards
1
Q
Introduction to the drug
A
Its a anti-fibromolytic which reduces the break down of the blood clotting
2
Q
How is the drug presented/ administered
A
- Oral tablet - 650mg x 2 3 times a day.
- 500mg in 5ml (100mg/1ml)
3
Q
Why would this drug be prescribed to a patient
A
- Pt’s with time critical injuries where internal/external haemorrhage is suspected
4
Q
What is the typical dose
A
- 1g initial dose IV ADULT
- 11/10yo 500mg
- 9yro 450mg
- 8yro 400mg
- 7yro 350mg
- 6/5yro 300mg
- 4yro 250mg
- 3/2yro 200mg
- 18/9mo 150mg
- 6/3mo 100mg
- birth,3mo 50mg
5
Q
What are the drugs actions Pharmacodynamics
A
Inhibits plasminogen activation and plasmic activity, preventing a clot breaking down rather than a new clot forming. It blocks the lysine binding sites on plasminogen which inhibits fibrinolysis.
6
Q
Pharmokinetics of the drug
A
- IV absorption,
- Vascular distribution,
- Metabolised hepatically,
- excreted renally
7
Q
What are the side effects of this drug
A
Rapid injection may cause hypotension.
