Metroclopramide

Question 1

Introduction

Answer 1

• Its a antiemetic acting on the CNS to reduce vertigo aswell as Gastrointestinal tract to reduce nausea and vomitting

Question 2

Presentation

Answer 2

• Ampoule 10mg in 2ml

Question 3

Why would you prescribe

Answer 3

• Nausea and vomitting in adults over 20yr

- Prevention and treatment of nausea, vomitting after morphine administration

Question 4

Typical dose

Answer 4

• 10mg in 2ml

Question 5

Pharmacodynamics

Answer 5

• Dopamine (5HT3) antagonist which acts on the GI tract
• Antagonises Dopamine receptors found in the chemorecptor trigger zone of the brain, which prevents nausea messages being sent to the vomitting centre
• Increase release of Acetylocholine in the GI tract, which increase tone in the lower part of the oesophagus

Question 6

Pharmakinetics

Answer 6

• Iv absorption
• Widely distributed
• Metabolised Hepactically
• Renally eliminated

Question 7

Side Effects

Answer 7

• Drowsiness or restlessness
• Cardiac abnormalities
• Diarrhoea