Hydrocortisone

Question 1

Introduction to the drug

Answer 1

• Glucocorticoid that reduces inflammation and suppresses the immune response

Question 2

Presentation of the drug

Answer 2

• Ampoule containing 100mg in 1ml

- Ampoule containing 100mg in 2ml of water

Question 3

Why would you prescribe the drug

Answer 3

• Severe or life threatening asthma
• Anaphylaxis
• Adrenal crisis

Question 4

Typical dose

Answer 4

• 100mg in 1ml slowly over a minimum of 2 minutes

Question 5

Pharmacodynamics of the drug

Answer 5

• Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.

Question 6

Pharmacokinetics of the drug

Answer 6

• Absorption
  Readily absorbed from the GI tract
• Distribution
  Crosses the placenta. Protein-binding: >90%.
• Metabolism
  Hepatic (metabolised to hydrogenated and degraded forms).
• Excretion
  Via urine

Question 7

Side effects

Answer 7

• Can cause burning or itching if administered too quickly