Gliclazide

Question 1

Introduction

Answer 1

• Its a Sulfonylurea (Increase the Beta cells release of Insulin)

Question 2

Pharmacodynamics

Answer 2

• Synthetic compund that stimulates Beta cells in the pancreas to release more Insulin
• Binds to the Beta Cell Sulfonylurea receptor which blocks ATP sensative potassium channels, resulting in a closer of the channels and leads to a decrease of potassium efflux, which leads to a depolerisation of the Beta cells

Question 3

Pharmacokenitcs

Answer 3

• Oral
• Widely
• Metabolised in the liver
• Kidneys