Syntometrine Flashcards
1
Q
- Introduction to the drug
A
- Used for post patnum haemorrhage within 24hrs of birth
2
Q
Presentation of the drug
A
- Ampoule 500mcg Ergometrine
- 5units in 1ml Oxytocin
3
Q
Why would you prescribe the drug
A
- Post partnum haemorrhage within 24hrs of birth with life threatening haemorrhage
4
Q
Typical dose
A
- 500mcg
5
Q
Pharmacodynamics
A
- Ergometrine and oxytocin cause the uterus to contract
- Ergometrine acts on the 5HT receptors which cause the muscles to contract
- Cause constrictions on vessels
- Oxytocin stimulates constriction of smooth muscle
6
Q
Pharmacokenitics
A
- IM absorption
- Widely distributed
- Metabolised hepactically
- Excreted Renally
7
Q
Side Effects
A
- Nausea and vomitting
- Abdominal pain
- Headache
- Hypertension and bradycardia
- Chest pain
