Glyceryl Trinitrate (GTN) Flashcards
1
Q
Introduction to the drug
A
- Potent Vasodilator of coronary arteries which when given results in lower preload and blood pressure
2
Q
Presentation
A
- Metered dose spray containing 400mcg GTN per dose
- Tablets 2,3,5 mg for buccal administration
3
Q
Why would you prescribe the drug
A
- Cardiac Pain
- MI
- Cardiogenic Pulmonary Oedema
4
Q
Typical dose
A
- 400mcg Spray
- 2,3,5 mg Buccal tablet
5
Q
Pharmacodynamics
A
- Releases nitric oxide in the blood which causes smooth muscle to relax and dilate
- Reduces after-load making the hearts workload and need for oxygen to reduce
6
Q
Pharmacokinetics
A
- Sublingual/Buccal absorption
- Widespread distribution
- Metabolised hepatic ally
- Excreted Renally
7
Q
Side effects
A
- Headache
- Dizziness
- Hypotension
