Chlorphenamine Flashcards
1
Q
Introduction to the drug
A
Chlorphenamine belongs to a group of medicines known as sedating antihistamines.
Exposure to certain substances can cause some people to produce an excess of a chemical called histamine. This causes allergic symptoms which can include swelling, skin rashes, sneezing, watery eyes, and a runny or blocked nose. Chlorphenamine blocks the effects of histamine, so it helps relieve allergic symptoms like these.
2
Q
Presentation of the drug
A
- Ampoule 10mg in 1ml
- Tablet 4mg
- Oral Solution 2mg in 5ml
3
Q
Why would you prescribe the drug
A
- Anaphylactic reaction
- Allergic reaction
4
Q
Typical dose
A
- IV/IO slowly over 1 minute
- IV 10mg in 1ml
- Tablet 4mg
- Oral 2mg in 5ml
5
Q
Pharmacodynamics of this drug
A
- Binds to the H1 receptor which block the action of histamine
6
Q
Side effects
A
- Sedation
- Dry mouth
- Headache
- Blurred Vision
- Pyschomotor impairment
Hypotension - Convulsions
7
Q
Pharmacokinetics of the drug
A
- Absorbed GI tract
- Widely distributed in the blood
- Metabolised hepatic ally
- Eliminated in the kidney
