Misoprosol Flashcards
1
Q
Introduction to the drug
A
- Obstetric prostaglandin
- Used in post-partnum haemorrhage within 24hrs of delivery in life threatening haemorrhage or miscarriage
2
Q
Presentation of the drug
A
- Tablet 200 mcg
3
Q
Why would you prescribe the drug
A
- Life threatening haemorrhage 24hrs after given birth
4
Q
Typical dose
A
- 600mcg 3x Tablets
5
Q
Pharmacodynamics
A
- Promotes uterine contractions by agonising 5-HT2 receptors and alpha adrenergic receptors
- Both upper and lower uterine segments are stimulated to contract
6
Q
Pharmacokinetics
A
- Oral absorption
- Widely distributed
- Metabolised in the liver
- Excreted in urine or faeces
7
Q
Side Effects
A
- Abdominal pain
- Nausea and vomiting
- Diarrhoea
- Pyrexia
- Shivering
