Paracetemol

Question 1

Introduction

Answer 1

• Analgesic and antipyrexic

Question 2

Presentation

Answer 2

• Tablets 500mg
• Oral solution 120mg in 5ml (3m-5yr)
• Oral solution 250mg in 5ml (5yr upwards)
• IV 1g in 100ml

Question 3

Why would you prescribe this drug

Answer 3

• Relief of moderate pain and high temperature

Question 4

Typical dose

Answer 4

• Adult tablet 1g every 4/6hrs, Max 4g in 24hrs

- IV 1g 4/6hrs Max 4/6hrs

Question 5

Pharmacodynamics

Answer 5

• Inhibits Prostaglandin formation, this reduces the signal and frequency of the pain signal to the brain
• Antipyrectic inhibition comes from inhibitation of the prostaglandins release in the hypothalamic centre

Question 6

Pharmacokenetics

Answer 6

• Absortion GI tract
• Widely Distributed
• Metabolised Hepactacally
• Excreted Renally