Tenectaplase Flashcards

1
Q

Introduction to the drug

A

Tenecteplase activates the fibronolytic system, inducing the breaking up of intravascular thrombi and emboli. In simple terms it helps the body produce a substance that dissolves unwanted blood clots.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How is the drug administered and presented

A
  • Vials 10,000 units for reconstitution with 10ml water for injection
  • Vials 8,000 units for reconstitution with 8ml water for injection
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why would you prescribe this drug

A
  • Acute STMI elevation within 6hrs of the onset where PPCI is NOT available
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Dose when administered of this drug

A
  • Administer a bolus injection of Heperin before Tenectaplase
<60kg = 6000units
60-69kg = 7000units
70-79kg = 8000units
80-89kg = 9000units
>90kg = 10000units
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What the drugs actions Pharmacodynamics

A
  • Activates the fibrinolytic system, inducing the breaking up of a intravascular thrombi and emboli
  • A relatively fibrin-selective plasminogen activator.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the side effects of the drug

A
  • Bleeding - Minor and major
  • Arrthymias
  • Anaphylaxis
  • Hypotension
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pharmacokinetics of the drug

A
  • Vascular distribution
  • Cleared by the liver.
  • ## Excreted Renally
How well did you know this?
1
Not at all
2
3
4
5
Perfectly