Ibuprofen Flashcards
1
Q
Introduction
A
- NSAID - Antiinflammatory, Antipyrexic, Analgesic
2
Q
Presentation
A
- Tablet 200mg or 400mg
- Solution 100mg in 5ml
3
Q
Why would you prescribe this drug
A
- Relief to moderate or high temperature and pain
- Soft tissue injury
4
Q
Typical dose
A
- Adult 400mg every 8hrs - Max 1.2g /24hr
5
Q
Pharmacodynamics
A
- Inhibits cyclooxygenase (COX) which inhibits the production of Prostaglandin synthesis
- COX catalyses the formation of Prostaglandin and thromboxane which act as the messenger molecule in the inflammatio process
- Inhibits platelet aggregation
- Increases pain threshold
6
Q
Pharmacokinetics
A
- Absorption GI tract
- Widely distributed
- Metabolised Hepactically
- Excreted really
7
Q
Side Effects
A
- May cause vomitting and diarrhoea
