ACE Inhibitors

Question 1

Introduction of the drug

Answer 1

• Angiotensin converting enzyme inhibitors (ACE inhibitors) are medications that slow (inhibit) the activity of the enzyme ACE, which decreases the production of angiotensin II. As a result, blood vessels enlarge or dilate, and blood pressure is reduced. This lower blood pressure makes it easier for the heart to pump blood and can improve the function of a failing heart. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed.

Question 2

Why would you prescribe the drug

Answer 2

• Controlling acute and chronic high blood pressure
• Treating left ventricular dysfunction and heart failure
• Preventing strokes
• Preventing and treating kidney disease (nephropathy) in people with hypertension or diabetes

Question 3

Pharmacodynamics of the drug

Answer 3

• Angiotensin converting enzyme inhibitors (ACE inhibitors) are medications that slow (inhibit) the activity of the enzyme ACE, which decreases the production of angiotensin II. As a result, blood vessels enlarge or dilate, and blood pressure is reduced. This lower blood pressure makes it easier for the heart to pump blood and can improve the function of a failing heart. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed.

Question 4

Side effects of the drug

Answer 4

• Cough
• Elevated blood potassium levels
• Low blood pressure,
• dizziness
• Headache
• Drowsiness
• Weakness
• Abnormal taste (metallic or salty taste)
• Rash
• Chest pain

Question 5

Generally Known as

Answer 5

• A-PRILs

Question 6

Pharmacokinetics

Answer 6

• Absorbed in the GI tract
• Metabolised Hepatically
• Excreted in the urine and faeces