Thyroid drugs

Question 1

Levothyroxine

Answer 1

T4 replacement
-increases metabolism, heart rate, GI motility, muscle development, gamete production
———
-hypothyroidism
——–
-tachycardia
-A-fib

Question 2

Liothyronine

Answer 2

T3 replacement
-increases metabolism, heart rate, GI motility, muscle development, gamete production
———
-hypothyroidism
——–
-tachycardia
-A-fib

Question 3

Radioiodine

Answer 3

-Releases beta particles which shred the thyroid
-takes a month to work
-avoid in children and pregnant peoples
——–
-hyperthyroidism
——-
-have to get T4 for the rest of their life

Question 4

Propylthiouracil

Answer 4

Thioamides contain S-C-N group
-Prevent synthesis of thyroid production
-prevent deiodination of T4
———
-hyperthyroidism
———
-takes 3-4 weeks to work
-skin rash 25%
-neutropenia
-agranulocytosis

Question 5

methimazole

Answer 5

Thioamides contain S-C-N group
-Prevent synthesis of thyroid production
———
-hyperthyroidism
———
-takes 3-4 weeks to work
-skin rash 25%
-neutropenia
-agranulocytosis

Question 6

Carbimazole

Answer 6

Thioamides contain S-C-N group
-prodrug of methimazole
-Prevent synthesis of thyroid production
———
-hyperthyroidism
———
-takes 3-4 weeks to work
-skin rash 25%
-neutropenia
-agranulocytosis

Question 7

Lugol iodine

Answer 7

/
Lots of iodine prevents thyroid action
——–
-surgery prep
-severe thyrotoxicosis
——–

Question 8

Propranolol (thyroid)

Answer 8

beta blocker
-treats Sx of hyperthyroidism
-protects the heart
-could reduce T4 to T3 conversion
———
-hyperthyroidism
———
-cold extremities
-rebound tachycardia