Anemia facts

Question 1

hypo chromic anemia

Answer 1

small RBC with low hemoglobin from chronic blood loss

Question 2

mageloblastic anemia

Answer 2

large RBC from B12 or folic acid deficiency

Question 3

pernicious anemia

Answer 3

fewer RBC from low intrinsic factor causing low b12

Question 4

haemolytic anemia

Answer 4

excessive destruction of RBCs

Question 5

iron doses

Answer 5

5mg for men
15mg for children or women
2-10times for pregnancy

Question 6

Iron kinetics

Answer 6

Ferrous iron Fe2+
by ferric reductase is absorbable by the duodenum, jejunum and upper ileum

Question 7

Senescent RBC

Answer 7

old RBC taken up by reticular system (macrophages and spleen)

Question 8

EPO action

Answer 8

Binds to intracellular receptors acting via tyrosine kisses to
-inhibit apoptosis
-proliferation via JAK2

Question 9

Colony stimulating factors MOA

Answer 9

Bind to myeloid progenitor cells which activate janus protein kinase and signal transducers and activators of transcription

Question 10

G-CSF side effects

Answer 10

-bone loss from increased osteoclasts
-joint pain from increased cytokines
-renal dysfunction from leukostasis plugging the kidneys
-respiratory distress from neutrophils activating in lungs
-splenic rupture
-sickle cell crises, compounds effect

Question 11

oprelvekin IL-11

Answer 11

megakaryocytic growth factor
-increases platelets
——
-dizziness
-headache
-fatigue

Question 12

Thrombopoietin

Answer 12

megakaryocytic growth factor
-increases platelets