Protein synthesis targeters facts Flashcards
1
Q
bacterial ribosome parts
A
50s (contains 23s) and 30s (contains a 16s) make 70s
2
Q
Tetracycline dosing
A
Do not take with food or any supplements with metal ions (no milk)
3
Q
Aminoglycosides penetration
A
oxygen dependent transport so not active for anaerobic bacteria
Also makes it build up in ear
4
Q
Aminoglycoside bacteriostatic
A
Irreversibly bind 30S trap at AUG
5
Q
aminoglycoside bactericidal
A
Has cationic effect binding surface membrane and creating pores to vent cell contents
6
Q
Macrolide Pharm K
A
concentrate in phagocytes
Significant inhibition of CYP450
7
Q
Quinolones concern
A
can have crazy bioaccumulation
8
Q
DNA gyrase and topoisomerase
A
Gyrase supercoils DNA, topoisomerase replicates DNA
9
Q
A
