Malaria drugs Flashcards
Quinine
Cinchona alkaloid
-prevents hemozion production and Hb proteolysis increasing ROA
——–
-Anti erythrocytic malaria
——–
-hypoglycemia
-dysrhythmias and A fib
-Cinchonism (nausea, tinnitus, visual issues)
Quinidine
Cinchona alkaloid
-prevents hemozion production and Hb proteolysis increasing ROA
——–
-Anti erythrocytic malaria
——–
-hypoglycemia
-dysrhythmias and A fib
-Cinchonism (nausea, tinnitus, visual issues)
Chloroquine
Cinchona alkaloid
-prevents hemozion production and Hb proteolysis increasing ROA
——–
-Anti erythrocytic malaria
-most effective and good for children and pregnant
——–
-hypoglycemia
-vasodilation
-arrhythmias
Mefloquine
Cinchona alkaloid
-prevents hemozion production and Hb proteolysis increasing ROA
——–
-Anti erythrocytic malaria
——–
-neuropsychiatric effects
-CNS toxicity
-aberrant atrioventricular conduction
Primaquine
Cinchona alkaloid ish?
-unknown, maybe ROA from ETC interference
——–
-Anti hepatic malaria
——–
-acute hemolysis (G6PD deficiency) reduces anti oxidant avaibility
Artemisinin
/
Becomes a free radical in food vacuole and inhibits calcium dependent ATPase in ER
——–
-anti asexual blood stage malaria
-used as combo with mefloquine or lumefantrine
——–
-Transient heart blood
-decrease in neutrophils
Proguanil
/
Similar to pyrimethamine as prodrug to cycloguanil DHFR inhibitor
——–
-anti hepatic stage malaria
Atovaquone
Ubiquinone analog
-inhibits mito cytochrome BC1 and inhibits ETC by decreasing membrane potential
———-
-anti asexual blood stage
——-
Tetracycline
tetracycline
-inhibits protein translation of plasmid
——–
-anti blood stage
-slow acting so used as combo
———
Doxycycline
tetracycline
-inhibits protein translation of plasmid
——–
-anti blood stage
-slow acting so used as combo
———
Sulfadoxine
sulfonamide
inhibits folic acid biosynthesis
——–
-anti malarial
-used with pyrimethamine
Pyrimethamine
sulfonamide
inhibits folic acid biosynthesis
——–
-anti malarial
-used with Sulfadoxine
